Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%**
Total Sugars
0 g
†
Incl. 0 g Added Sugars
0%**
Intelliflora™ Blend:
150 mg5 billion CFUs
Lactobacillus crispatus LBV 88
†
Lactobacillus rhamnosus LBV 96
†
Lactobacillus gasseri LBV 150N
†
Lactobacillus jensenii LBV 116
†
Top Medical Research Studies
9
We explored the potential of Lactobacillus strain LC-STH-13 in treating systemic lupus erythematosus (SLE), a challenging autoimmune disorder. Using female MRL/lpr mice prone to lupus, we found that LC-STH-13 significantly lowered anti-autoantibodies and optimized the balance of immune cells.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Read More
9
We aimed to understand whether probiotics could ease inflammation in autoimmune pancreatitis (AIP) by interfacing with innate immunity. We set up a mouse model of AIP and treated these mice with Lactobacillus gasseri. The treatment appeared to significantly reduce pancreatitis symptoms, potentially via TLR7 signaling in immune cells.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
Most Useful Reviews
9
Significant comfort improvement
11 people found this helpful
I decided to order these probiotics for my wife, who often suffers from thrush. After starting the treatment, she noticed much more comfort in the intimate area. Even after daily intimacy, there is no more discomfort as before. My wife also appreciated this effect. A month has passed since completing the course, and the effect is still holding strong. My wife states they are very good probiotics.
Read More
10
Inflammation greatly reduced
2 people found this helpful
These capsules are incredibly useful. I ordered them for inflammation, and thankfully, it has nearly disappeared after suffering for seven months. Thank you!
Read More
7.5
Positive results noted
4 people found this helpful
It seems the medication is working; the discharge has significantly decreased. I will keep monitoring. I am already on my third package; my microflora feels excellent!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
- All Researches
9
We examined how probiotics affect immune cells in rheumatoid arthritis (RA) patients. By isolating monocytes from both RA patients and healthy individuals, we created macrophages that were treated with different probiotic bacteria.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Read More
9
We explored the potential of Lactobacillus strain LC-STH-13 in treating systemic lupus erythematosus (SLE), a challenging autoimmune disorder. Using female MRL/lpr mice prone to lupus, we found that LC-STH-13 significantly lowered anti-autoantibodies and optimized the balance of immune cells.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Read More
9
We investigated how diet influences autoimmune diseases, particularly using a ketogenic diet (KD) model. The KD improved conditions in a mouse model of multiple sclerosis by interacting with the gut microbiome.
Notably, lactobacillus variants were linked to reduced immune cell activation. We found that a specific strain, L. murinus, offered protection against autoimmune conditions, demonstrating the potential of lactobacillus combined with diet-dependent compounds to impact immunity positively.
Overall, our findings underscore the importance of dietary factors and gut bacteria in managing autoimmune disorders.
Notably, lactobacillus variants were linked to reduced immune cell activation. We found that a specific strain, L. murinus, offered protection against autoimmune conditions, demonstrating the potential of lactobacillus combined with diet-dependent compounds to impact immunity positively.
Overall, our findings underscore the importance of dietary factors and gut bacteria in managing autoimmune disorders.
Read More
9
We aimed to understand whether probiotics could ease inflammation in autoimmune pancreatitis (AIP) by interfacing with innate immunity. We set up a mouse model of AIP and treated these mice with Lactobacillus gasseri. The treatment appeared to significantly reduce pancreatitis symptoms, potentially via TLR7 signaling in immune cells.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
This suggests that Lactobacillus could be a valuable tool in managing AIP, as we observed crucial interactions between the gut microbiota and the body's immune response.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant comfort improvement
11 people found this helpful
I decided to order these probiotics for my wife, who often suffers from thrush. After starting the treatment, she noticed much more comfort in the intimate area. Even after daily intimacy, there is no more discomfort as before. My wife also appreciated this effect. A month has passed since completing the course, and the effect is still holding strong. My wife states they are very good probiotics.
Read More
10
Inflammation greatly reduced
2 people found this helpful
These capsules are incredibly useful. I ordered them for inflammation, and thankfully, it has nearly disappeared after suffering for seven months. Thank you!
Read More
7.5
Positive results noted
4 people found this helpful
It seems the medication is working; the discharge has significantly decreased. I will keep monitoring. I am already on my third package; my microflora feels excellent!
Read More
6
Partial improvement achieved
1 people found this helpful
I took these to support my therapy for systemic candidiasis due to the lactobacilli composition. Initially, I saw no changes, but painful secretions returned and subsided in three days on their own. While I didn’t see digestive effects, I hope my microbiome has improved, and I will order again despite the cost.
Read More
Frequently Asked Questions
10
Inflammation greatly reduced
2 people found this helpful
These capsules are incredibly useful. I ordered them for inflammation, and thankfully, it has nearly disappeared after suffering for seven months. Thank you!
6
Partial improvement achieved
1 people found this helpful
I took these to support my therapy for systemic candidiasis due to the lactobacilli composition. Initially, I saw no changes, but painful secretions returned and subsided in three days on their own. While I didn’t see digestive effects, I hope my microbiome has improved, and I will order again despite the cost.
9
Significant comfort improvement
11 people found this helpful
I decided to order these probiotics for my wife, who often suffers from thrush. After starting the treatment, she noticed much more comfort in the intimate area. Even after daily intimacy, there is no more discomfort as before. My wife also appreciated this effect. A month has passed since completing the course, and the effect is still holding strong. My wife states they are very good probiotics.
7.5
Positive results noted
4 people found this helpful
It seems the medication is working; the discharge has significantly decreased. I will keep monitoring. I am already on my third package; my microflora feels excellent!
9
We examined how probiotics affect immune cells in rheumatoid arthritis (RA) patients. By isolating monocytes from both RA patients and healthy individuals, we created macrophages that were treated with different probiotic bacteria.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
Our findings revealed that probiotic treatment shifted macrophages towards a more anti-inflammatory state while reducing markers of inflammation. Notably, probiotics increased levels of beneficial anti-inflammatory substances and decreased harmful inflammatory responses.
This suggests probiotics could play a role in managing RA through their influence on immune cell behavior.
9
We explored the potential of Lactobacillus strain LC-STH-13 in treating systemic lupus erythematosus (SLE), a challenging autoimmune disorder. Using female MRL/lpr mice prone to lupus, we found that LC-STH-13 significantly lowered anti-autoantibodies and optimized the balance of immune cells.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
Additionally, it reduced kidney inflammation by targeting the TLR9/NF-κB signaling pathway and improved gut health. These results are promising, suggesting that LC-STH-13 could be a safe and effective treatment avenue for SLE.
9
We investigated how diet influences autoimmune diseases, particularly using a ketogenic diet (KD) model. The KD improved conditions in a mouse model of multiple sclerosis by interacting with the gut microbiome.
Notably, lactobacillus variants were linked to reduced immune cell activation. We found that a specific strain, L. murinus, offered protection against autoimmune conditions, demonstrating the potential of lactobacillus combined with diet-dependent compounds to impact immunity positively.
Overall, our findings underscore the importance of dietary factors and gut bacteria in managing autoimmune disorders.
Notably, lactobacillus variants were linked to reduced immune cell activation. We found that a specific strain, L. murinus, offered protection against autoimmune conditions, demonstrating the potential of lactobacillus combined with diet-dependent compounds to impact immunity positively.
Overall, our findings underscore the importance of dietary factors and gut bacteria in managing autoimmune disorders.
8
We conducted a randomized, double-blind study to see how synbiotics could influence systemic lupus erythematosus (SLE) disease activity. Fifty patients were split into two groups—one received standard care and synbiotics, while the other had standard care only.
The results were promising; the synbiotics group showed a notable decrease in inflammatory markers and disease activity compared to their initial conditions. Meanwhile, the placebo group didn't see significant changes.
While our findings suggest synbiotics could be a helpful addition to SLE treatment, more research is necessary to understand how they work.
The results were promising; the synbiotics group showed a notable decrease in inflammatory markers and disease activity compared to their initial conditions. Meanwhile, the placebo group didn't see significant changes.
While our findings suggest synbiotics could be a helpful addition to SLE treatment, more research is necessary to understand how they work.
References
- Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. 10.1002/fsn3.70068
- Kazemimiraki M, Moazamian E, Mokhtari MJ, Gholamzad M. The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat. Neuromolecular Med. 2025;27:14. 10.1007/s12017-025-08837-1
- Qu H, Fu XX, Han S. C16 peptide and angiopoietin-1 alleviate the side effects of glucocorticoids in a rat multiple sclerosis model. Life Sci. 2025;363:123402. 10.1016/j.lfs.2025.123402
- Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. 10.1039/d4fo03966a
- Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, et al. A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity. Cell Rep. 2024;43:114891. 10.1016/j.celrep.2024.114891
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Gangaiah D, Gu M, Zaparte A, Will O, Dolan LC, et al. Effects of Limosilactobacillus reuteri strains PTA-126787 and PTA-126788 on intestinal barrier integrity and immune homeostasis in an alcohol-induced leaky gut model. Sci Rep. 2024;14:19584. 10.1038/s41598-024-70549-6
- Straus Farber R, Walker EL, Diallo F, Onomichi K, Riley C, et al. A randomized cross-over trial of prebiotics and probiotics in multiple sclerosis: Trial feasibility, supplement tolerability and symptom abatement. Mult Scler Relat Disord. 2024;89:105762. 10.1016/j.msard.2024.105762
- Sprenger-Svačina A, Klein I, Svačina MKR, Bobylev I, Kohle F, et al. Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN). J Neuroimmune Pharmacol. 2024;19:26. 10.1007/s11481-024-10119-9
- Ito S, Higashiyama M, Nishimura H, Tomioka A, Tanemoto R, et al. The Role of Gut Microbiota and Innate Immune Response in an Autoimmune Pancreatitis Model. Pancreas. 2024;53:e617. 10.1097/MPA.0000000000002339
- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. 10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. 10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. 10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. 10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. 10.3389/fmed.2023.1085578
- Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. 10.1038/s41419-023-05589-3
- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. 10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. 10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. 10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. 10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. 10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. 10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. 10.1002/jcp.26819
